Nkhani

Alprostadil, yomwe imatchedwanso kuti PGE1, ndi mtundu wa zinthu zopangira mankhwala, zomwe zimagwiritsidwa ntchito kwambiri pazamankhwala ndi madera okhudzana nawo.Imapezeka ngati jekeseni kapena mu mawonekedwe a suppositories ndi zonona zapakhungu zochizira.Monga chimodzi mwa zigawo zikuluzikulu zomwe zimagwiritsidwa ntchito popanga prostaglandin E1 (PGE1) zotumphukira, alprostadil imagwira ntchito yofunika kwambiri pakukulitsa mitsempha yamagazi ndikuwongolera kuthamanga kwa magazi m'malo ena a minofu kwa odwala omwe ali ndi vuto la erectile (ED).Kafukufuku wachipatala atsimikizira kuti alprostadil imathandizira bwino erections mwa kutulutsa nitric oxide, yomwe imapangitsa maselo osalala a minofu omwe akugwira nawo ntchito yomanga.Kuonjezera apo, zasonyezedwa kuti zimagwira ntchito mofulumira kwambiri kusiyana ndi mankhwala apakamwa achikhalidwe akamaperekedwa kudzera mwa intracavernous kapena intraurethralally.

Pankhani ya pharmacological kanthu, alprostadil makamaka amachita monga prostaglandin cholandilira agonist, ndi prostaglandin zolandilira zimapezeka thupi lonse la munthu.Izi zimapanga zotsatira monga vasodilation, zomwe zimapangitsa kuti magazi aziyenda bwino;bronchoconstriction kuchepetsa zizindikiro za mphumu;zotheka kuchepetsa apoptosis mu matenda okhudzana ndi khansa;kuchepetsa kutupa, ndi zina.Zomwe zimakhala ndi ntchito zambiri zimapangitsa kuti zikhale zofunikira kwambiri pamapulogalamu osiyanasiyana opanga mankhwala, kuchokera ku chithandizo cha ED kupita ku chithandizo cha khansa ndi zina zambiri, malingana ndi vuto lenileni limene mankhwala omaliza ayenera kuthana nawo.

Kuwonjezera pa kukhala makonda kwa achire zolinga zosiyanasiyana matenda kudzera utsogoleri njira monga jekeseni kapena suppository mafomu;poyerekeza ndi zinthu zofanana pamsika, PGE1 imawonetsanso zotsatira zoyipa, kuphatikizapo kupweteka kwa mutu pambuyo pogwiritsira ntchito, mpaka Kufooka kwathunthu pambuyo pa maola angapo;ngakhale kuti nthawi zina zimachitika, nthawi zambiri samachitapo kanthu motsatira mlingo wotchulidwa, kuyambira ndi malangizo ogwiritsira ntchito nthawi yaitali omwe amaperekedwa ndi zolemba za dokotala.Kuphatikiza apo, malinga ndi kafukufuku waposachedwa wa sayansi wochitidwa padziko lonse lapansi, nthawi zambiri, nthawi yoyambira kuchitapo kanthu imasiyanasiyana kuchokera pa mphindi 15 mpaka mphindi 30 zokha, koma mwachilengedwe zotsatira zake zimadalira kwambiri momwe wodwalayo alili.

Ponseponse, PGE1 idawonetsa phindu lodabwitsa, makamaka mwa amuna omwe ali ndi vuto logonana komanso vuto lakuthupi Njira zochiritsira zomwe zidalembedwa kale zalephera chifukwa chosowa mphamvu komanso zovuta zomwe zikuchitikazi ziyenera kuthetsedwa mokwanira, osadandaula za thanzi lililonse. zovuta, zomwe zimapangitsa kuti ikhale yotetezeka komanso yotheka.