Zogulitsa

Afoxolaner ndi systemicmankhwala ophera tizilombondiacaricidezomwe zimaperekedwa pakamwa kapena pamutu.

Afoxolaner amaletsaγ-aminobutyric acid(GABA) -njira za chloride (GABAA receptors) ndi L-glutamate-Gated chloride njira (GluCls).Mphamvu ya Afoxolaner ikufanana ndimankhwala fipronil.

Ndi mankhwala ambiri ophera tizilombo omwe ali ndi ntchito yabwino yophera nkhupakupa, utitiri, nsabwe, hemiptera ndi diptera, ndipo ukali wake ndi wapamwamba kuposa kapena wofanana ndi wa mankhwala omwe amagwiritsidwa ntchito kwambiri.

Zachipatala zikuwonetsa kuti Afoxolaner imatha kupereka chitetezo chanthawi yayitali kwa milungu 12 kwa agalu kuti azitha kutulutsa ectoparasite.Ndiosavuta komanso yothandiza kwa ziweto ndi ziweto.

Imatha kutulutsa ndi kupha utitiri kwa agalu.Zitha kugwira ntchito mwachangu pa utitiri wachikulire ndikukhala kwa nthawi yayitali.Zingathenso kuteteza utitiri kuti zisalowe mazira, motero kuwononga moyo wa utitiri.Izi wamba pet ectoparasites zimatenga zakudya nyama, ndipo angathenso kufalitsa matenda ambiri, monga mphutsi zopsereza, Lyme matenda, nkhalango encephalitis, etc. Sizidzangokhudza kukula ndi thanzi la ziweto, komanso kubweretsa zoopsa za thanzi kwa eni ziweto.Afoxolaner alibe ntchito pa mammalian mantha dongosolo zolandilira, kotero ndi otetezeka kwambiri kwa nyama zoyamwitsa.

Afoxolaner pafupifupi kuwola ndi nyama zazing'ono.Mawonekedwe oyambilira a maselo ozungulira 90-100% amatulutsidwa kudzera mu ndowe popanda metabolites.Pafupifupi palibe excretion aimpso, kwambiri chitetezo, palibe kuwonongeka kwa chiwindi ndi impso nyama zazing'ono.

Ilibe zoletsa zotsutsana ndi mankhwala komanso sizigwirizana ndi mankhwala, ndipo sizilimbana ndi mankhwala omwe alipo kale.Pambuyo pakamwa, mankhwalawa amagawidwa mofanana pa thupi.Imayamba kugwira ntchito 2 hours pambuyo pakamwa makonzedwe.Pambuyo pa maola anayi, imatha kupha pafupifupi 80% ya tizilombo.Nthawi yachitetezo imatha kufika masabata 12.Matenda obwerezabwereza amathanso kupeza zotsatira zabwino kwambiri zothamangitsira tizilombo.Ndi mtundu wa antibody ectoparasite mankhwala okhala ndi chitetezo chokwanira, omwe ndi ofunika kwambiri kugwiritsa ntchito.