Tulathromycin 217500-96-4 Antibiotic Antifungal
Malipiro:T/T, L/C
Koyambira:China
Port Yotumizira:Beijing / Shanghai / Hangzhou
Mphamvu zopanga:400kg / mwezi
Order(MOQ):25kg pa
Nthawi yotsogolera:3 Masiku Ogwira Ntchito
Malo osungira:Kusungidwa mu ozizira, youma, firiji.
Zamkatimu:ng'oma
Kukula kwa phukusi:25kg / ng'oma
Zambiri zachitetezo:Osati zinthu zoopsa
Mawu Oyamba
Tulathromycin, ndi antibacterial antibacterial wothandizira komanso antibacterial zochita motsutsana ndi mabakiteriya a gram-positive ndi gram-negative.Amakhudzidwa kwambiri ndi tizilombo toyambitsa matenda a kupuma kwa ng'ombe ndi nkhumba, monga Actinobacillus pleuropneumoniae, Pasteurella haemolyticus, Pasteurella haemorrhagica, histophilus sleep (Haemophilus sleep), Mycoplasma pneumoniae, Haemophilus parasuis, Bordetella bronchiseptica, etc.
Makhalidwe a pharmacokinetic a Tulathromycin ndikuti mutatha kuwongolera mlingo umodzi, imalowetsedwa mwachangu pamalo opangira jakisoni, kuchuluka kwa magazi m'magazi kumasungidwa kwa nthawi yayitali, kuchotsedwa kumachepa, kuchuluka kwa kugawa kumakhala kwakukulu, bioavailability ndi yayikulu, ndipo ndende mu minofu yotumphukira ndi yayikulu kuposa ya plasma.Kugawa kwakukulu kwa minofu ndi kufalikira kwa maselo abwino ndizofunikira kwambiri za kagayidwe ka Tulathromycin.Kuchulukana m'maselo a chitetezo cha mthupi ndi chinthu chofunikira kwambiri cha Tulathromycin.
Tulathromycin imalepheretsa kaphatikizidwe ka mapuloteni a bakiteriya mwa kutsekereza njira yotumizira ma peptide bakiteriya.Chifukwa cha zolakwika zina za erythromycin, anthu amafunikira mankhwala ena m'malo mwa erythromycin mwachangu.Tulathromycin ndi mtundu watsopano wa macrolide semi synthetic antibiotic wa nyama.Zili ndi ubwino wambiri, monga mlingo wochepa, kayendetsedwe ka nthawi imodzi, zotsalira zochepa, zinyama ndi zina zotero.Sikuti ali ndi ubwino wa macrolide mankhwala, komanso ali kopitilira muyeso wautali theka la moyo umene uli wapamwamba kuposa maantibayotiki ena macrolide.Kutengera ubwino kukhalabe ogwira achire ndende mu thupi kwa nthawi yaitali, akhoza kukwaniritsa bwino bacteriostasis ndi yolera yotseketsa.
Pambuyo kwambiri kuchipatala ntchito, tulathromycin ali zoonekeratu achire zotsatira kupuma ng'ombe ndi nkhumba matenda.Tithokoze chifukwa champhamvu kwambiri yolimbana ndi mabakiteriya a Tulathromycin ngati mlingo wocheperako wogwiritsa ntchito, theka la moyo wautali komanso nthawi imodzi, utha kugwiritsidwa ntchito kwambiri.
Tulathromycin ndi wamphamvu kuposa macrolides omwe amagwiritsidwa ntchito kwambiri pamsika pano, monga tylosin, tilmicosin ndi florfenicol.Zomwe zili ndi ntchito zazikulu zomwe zingatheke.
Chonde dziwani kuti Tulathromycin ndi yotetezeka, yopanda carcinogenicity, teratogenicity ndi genotoxicity.Sichingapangitse kusintha kwa majini, koma kungayambitse cardiotoxicity.Ayenera kutsatira malangizo a Chowona Zanyama.
Kufotokozera (In House Standard)
| Kanthu | Kufotokozera |
| Maonekedwe | White kapena pafupifupi ufa woyera |
| Kusungunuka | Amasungunuka momasuka mu methanol, acetone, ndi methyl acetate, sungunuka mu ethanol. |
| Kuzungulira kwapadera kwa kuwala | -22 ° mpaka -26 ° |
| Chizindikiritso | HPLC: nthawi yosungira pachimake chachikulu mu chromatogram yokonzekera kuyesa imafanana ndi yomwe ili mu chromatogram ya kukonzekera kwa strandard komwe kumapezeka monga momwe zafotokozedwera mu assay. IR: Mawonekedwe a IR amagwirizana ndi CRS |
| Madzi | ≤2.5% |
| Zotsalira pakuyatsa | ≤0.10% |
| Zitsulo zolemera | ≤20ppm |
| Zogwirizana nazo | Chidetso chonse ≤6.0% Chidetso chamunthu ≤3.0% |
| Bakiteriya endotoxin | <2 EU |
| Assay (zinthu zopanda madzi) | 95% -103% |
| Zosungunulira zotsalira | N-Heptane≤5000ppm Dichloromethane ≤600ppm |
| Kuyesa | Zomwe zili mu C41H79N3O1295% -103% (Pamtundu wa Anydrous) |
