Tacrolimus monohydrate 109581-93-3 Antibiotic
Malipiro:T/T, L/C
Koyambira:China
Port Yotumizira:Beijing / Shanghai / Hangzhou
Mphamvu zopanga:1kg/mwezi
Order(MOQ):1g
Nthawi yotsogolera:3 Masiku Ogwira Ntchito
Malo osungira:Kusungidwa mu ozizira, youma, firiji.
Zamkatimu:botolo, botolo
Kukula kwa phukusi:1 g / botolo, 5 / botolo, 10g / mbale, 50g / botolo, 500g / botolo
Zambiri zachitetezo:UN 2811 6.1/PG 3
Mawu Oyamba
Tacrolimus, ndi immunosuppressive mankhwala.Pambuyo poika chiwalo cha allogeneic, chiopsezo chokana chiwalo chimakhala chochepa.Kuti muchepetse chiopsezo cha kukanidwa kwa chiwalo, tacrolimus imaperekedwa.Mankhwalawa amathanso kugulitsidwa ngati mankhwala apakhungu pochiza matenda a T-cell-mediated monga eczema ndi psoriasis.Itha kugwiritsidwa ntchito pochiza matenda amaso amphaka ndi agalu.
Tacrolimus imalepheretsa calcineurin, yomwe imagwira ntchito yopanga interleukin-2, molekyulu yomwe imalimbikitsa kukula ndi kufalikira kwa maselo a T, monga gawo la thupi lomwe limaphunzira (kapena kusintha) chitetezo cha mthupi.
Kufotokozera (USP43)
| Kanthu | Kufotokozera |
| Maonekedwe | White kapena pafupifupi woyera crystalline ufa |
| Chizindikiritso | IR, HPLC |
| Kusungunuka | Kusungunuka kwambiri mu methanol, kusungunuka mwaulere mu N,N dimethylformamide komanso mu mowa, pafupifupi sungunuka m'madzi. |
| Zotsalira pakuyatsa | ≤0.10 % |
| Zonyansa zakuthupi (ndondomeko-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50% | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-propyl analogi ≤0.15% | |
| Chidetso chosadziwika -I ≤0.10 % | |
| Chidetso chosadziwika -II ≤0.10 % | |
| Chidetso chosadziwika -III ≤0.10 % | |
| Zonse zosafunika ≤1.00% | |
| Kuzungulira kwa kuwala (monga momwe zilili) (10mg/ml in N,Ndimethylformamide) | -110.0° ~ -115.0° |
| M'madzi (mwa KF) | ≤4.0% |
| Zosungunulira zotsalira (zolemba GC) | Acetone ≤1000ppm (M'nyumba) |
| Di-isopropyl ether ≤100ppm (M'nyumba) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Mayeso a Microbial (m'nyumba) | Chiwerengero chonse cha ma aerobic microbial ≤100cfu/gm |
| Chiwerengero chonse cha yisiti ndi nkhungu ≤10cfu/gm | |
| Zamoyo zodziwika bwino (Tizilombo toyambitsa matenda) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) siziyenera kukhalapo | |
| Assay (wolemba HPLC) (pa anhydrous and solvent free basis) | 98% ~ 102% |
