Orlistat 96829-58-2 Antiobesity Diet supplement
Malipiro:T/T, L/C
Koyambira:China
Port Yotumizira:Beijing / Shanghai / Hangzhou
Mphamvu zopanga:800kg / pamwezi
Order(MOQ):25kg pa
Nthawi yotsogolera:3 Masiku Ogwira Ntchito
Malo osungira:Kusungidwa mu ozizira, youma, firiji.
Zamkatimu:ng'oma
Kukula kwa phukusi:25kg / ng'oma
Zambiri zachitetezo:Osati zinthu zoopsa
Mawu Oyamba
Orlistat ndi choletsa cham'mimba cha lipase inhibitor chomwe chimagwira nthawi yayitali komanso champhamvu.Ndi woyera kapena pafupifupi ufa woyera kutentha firiji, amene insoluble m'madzi, sungunuka chloroform, ndipo mosavuta sungunuka Mowa.Imalepheretsa puloteniyo ndikupanga ma covalent bond ndi malo omwe ali ndi serine a chapamimba lipase ndi pancreatic lipase m'mimba ndi m'matumbo ang'onoang'ono.
Orlistat ndi mtundu wa lipase inhibitor wochepetsa thupi.Ndi hydrated yochokera ku lipstatin, yomwe imatha kuchepetsa kuyamwa kwamafuta a chakudya ndikuchepetsa kulemera.Izi zimakhala ndi chopinga champhamvu komanso chosankha cha m'mimba lipase ndi pancreatic lipase, sichimakhudza ma enzyme ena am'mimba (amylase, trypsin, chymotrypsin) ndi phospholipase, ndipo sichikhudza kuyamwa kwa chakudya, mapuloteni ndi phospholipids.Imalepheretsa puloteniyo makamaka pomanga molumikizana ndi zotsalira za serine pamalo omwe akugwira ntchito m'mimba lipase ndi pancreatic lipase m'mimba, imalepheretsa hydrolysis ya triacylglycerol, imachepetsa kudya kwa monoglyceride ndi acid yaulere yamafuta, motero imawongolera kulemera kwa thupi.Mankhwala samatengedwa ndi m'mimba thirakiti, ndipo kuletsa kwa lipase ndikosinthika.
Chida ichi chilinso ndi ntchito yowongolera lipids m'magazi.Ikhoza kuchepetsa triglyceride ndi low-density lipoprotein cholesterol mu seramu ya odwala onenepa kwambiri ndikuwonjezera kuchuluka kwa lipoprotein apamwamba kwambiri mpaka otsika osalimba lipoprotein.
Orlistat ikaphatikizidwa ndi zakudya zotsika zama calorie, ndizoyenera kuchiza kwanthawi yayitali anthu onenepa kwambiri komanso onenepa kwambiri, kuphatikiza omwe adakulitsa ziwopsezo zokhudzana ndi kunenepa kwambiri.Imakhala ndi ntchito yoletsa kulemera kwanthawi yayitali monga kuonda, kuwongolera kunenepa komanso kupewa kubwereranso.Zachipatala zikuwonetsa mwachiwonekere kuti ntchito yowongolera kulemera ndiyothandiza kwambiri pakugwiritsa ntchito kwanthawi yayitali mukamadya kapena mutatha ola limodzi lachakudya.
Orlistat imatha kuchepetsa kuchuluka kwa ziwopsezo zokhudzana ndi kunenepa kwambiri komanso matenda ena okhudzana ndi kunenepa kwambiri, kuphatikiza hypercholesterolemia, matenda amtundu wa 2, kulolerana kwa shuga, hyperinsulinemia, matenda oopsa, komanso kuchepetsa mafuta m'thupi.
Kufotokozera (USP42)
| Kanthu | Kufotokozera |
| Chizindikiritso | HPLC, IR |
| Kuzungulira kwapadera kwa kuwala | -48.0°~-51.0° |
| Zomwe zili m'madzi | ≤0.2% |
| Zinthu zokhudzana ndi I | Orlistat yokhudzana ndi gulu A ≤0.2% |
| Zogwirizana ndi II | Ogwirizana ndi Orlistat B ≤0.05% |
| Zinthu zogwirizana III
| Formylleucine ≤0.2% |
| Orlistat yokhudzana ndi C ≤0.05% | |
| Orlistat tsegulani mphete epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Chidetso chamunthu payekhapayekha ≤0.1% | |
| Zogwirizana ndi IV | Orlistat yokhudzana ndi gulu D ≤0.2% |
| Orlistat lotseguka mphete amide ≤0.1% | |
| Zinthu zokhudzana ndi V | Ogwirizana ndi Orlistat E ≤0.2% |
| Zonyansa zonse (I mpaka V) | ≤1.0% |
| Zotsalira zosungunulira | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Zotsalira pakuyatsa | ≤0.1% |
| Zitsulo zolemera ngati Pb | ≤20ppm |
| Kuyesedwa kwa HPLC | 98.0% ~ 101.5% (pa anhydrous, zopanda zosungunulira) |
