Zogulitsa

Glutathione imatha kuchepetsedwa (GSH), oxidized (GSSG), kapena mitundu yosakanikirana ya disulfide ndipo imapezeka paliponse muzinthu zambiri zamoyo zomwe zimakhala ngati thiol-disulfide redox buffer yayikulu ya cell.Glutathione, Oxidized (GSSG) ndiye mtundu wa okosijeni wachilengedwe komanso wofunikira kwambiri wa antioxidant glutathione (GSH).Mu vivo GSSG imachepetsedwa kubwerera ku GSH kudzera mu NADPH-yodalira enzyme glutathione reductase.Chiyerekezo cha GSH ndi GSSG nthawi zambiri chimagwiritsidwa ntchito poyesa kuchuluka kwa kupsinjika kwa okosijeni m'maselo, okhala ndi kuchuluka kwa GSSG kutanthauza kupsinjika kwa okosijeni, chifukwa chake kukhala chizindikiro chofunikira kwambiri chaumoyo wama cell.GSSG imagwira ntchito ngati wolandila haidrojeni pakutsimikiza kwa enzymatic ya NADP+ ndi NADPH ndipo itha kukhala wopereka mopitilira muyeso wa S-glutathionylation pomasulira zosintha.GSSG, pamodzi ndi glutathione ndi S-nitrosoglutathione (GSNO), zapezeka kuti zimamangiriza kumalo ovomerezeka a glutamate a NMDA ndi AMPA receptors (kudzera m'magulu awo a γ-glutamyl), ndipo akhoza kukhala amtundu wa neuromodulators.GSSG itha kugwiritsidwa ntchito ngati gawo lapansi poyesa glutathione reductase.